Spatial reasoning is critical in all areas of modern chemistry and biochemistry. A lack of such skills leads to chemical misconceptions and a shortcoming in understanding relevant molecular representation(s). At the university, the average student's three-dimensional (3D)-reasoning skills are not developed enough to match the level required in future industrial or academic positions. Currently, there are no effective approaches that address this issue. We initiated this project to research and develop a novel classroom-activating tool to mitigate this shortcoming. By combining our experience with 3D molecular modelling software and didactic method development, we designed a platform that brings 3D and virtual reality (VR) representations of biomacromolecules (e.g., proteins; DNA) and small molecules (e.g., drugs; enzyme substrates) to the classroom. One of the goals was to develop a tool that runs on mobile phones and provides VR capabilities through low-cost cardboard VR goggles. Another goal was to develop a heuristic teaching method that actively allows students to develop spatial reasoning skills using 3D and VR tools. The 3D/VR tool was integrated with two conventional first-year BSc biochemistry lecture series and was well-received by students. The impact it has on students was investigated using online and post-course questionnaires. Overall, students were enthusiastic, well-engaged, and perceived the intervention contributed to their spatial reasoning skills

Authors:
Jacqueline Van Muijlwijk-Koezen, Vrije Universiteit Amsterdam, Netherlands
Anton R. Blaazer, Vrije Universiteit Amsterdam, Netherlands

About the Presenter(s)
Professor Jacqueline van Muijlwijk-Koezen is a University Professor/Principal Lecturer at Vrije Universiteit Amsterdam in Netherlands

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